Webb D B, MacKenzie R, Zoob S N, Rees A J
Clin Sci (Lond). 1985 Dec;69(6):687-9. doi: 10.1042/cs0690687.
The accelerated model of nephrotoxic serum nephritis (NTSN) was produced in 12 Sprague-Dawley rats. Six of these rats were administered superoxide dismutase (EC 1.15.1.1; SOD) subcutaneously (8 mg/kg) 8-hourly for 4 days. The first dose was given 6 h before the nephrotoxic serum (NTS). The progression of renal disease was monitored by following (i) albumin excretion, (ii) serum creatinine and creatinine clearance and (iii) renal histopathology and immunofluorescence. There was no evidence that SOD influences the course of NTSN. SOD was scarcely excreted by control rats or rats with NTSN.
在12只斯普拉格-道利大鼠中建立了肾毒性血清肾炎（NTSN）加速模型。其中6只大鼠每8小时皮下注射超氧化物歧化酶（EC 1.15.1.1；SOD）（8 mg/kg），持续4天。第一剂在注射肾毒性血清（NTS）前6小时给予。通过以下方式监测肾脏疾病的进展：（i）白蛋白排泄；（ii）血清肌酐和肌酐清除率；（iii）肾脏组织病理学和免疫荧光。没有证据表明SOD会影响NTSN的病程。对照大鼠或患有NTSN的大鼠几乎不排泄SOD。
