动态 3'-脱氧-3'-[F]氟代胸苷 ([F]FLT) PET 采集需要多长时间才能进行稳健的乳腺癌动力学分析？
How Long of a Dynamic 3'-Deoxy-3'-[F]fluorothymidine ([F]FLT) PET Acquisition Is Needed for Robust Kinetic Analysis in Breast Cancer?
机构信息
Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Room 430, Columbus, OH, 43210-1228, USA.
Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
出版信息
Mol Imaging Biol. 2019 Apr;21(2):382-390. doi: 10.1007/s11307-018-1231-x.
PURPOSE
To quantitatively evaluate the minimally required scanning time of 3'-deoxy-3'-[F]fluorothymidine ([F]FLT) positron emission tomography (PET) dynamic acquisition for accurate kinetic assessment of the proliferation in breast cancer tumors.
PROCEDURES
Within a therapeutic intervention trial, 26 breast tumors of 8 breast cancer patients were analyzed from 30-min dynamic [F]FLT-PET acquisitions. PET/CT was acquired on a Gemini TF 64 system (Philips Healthcare) and reconstructed into 26 frames (8 × 15 s, 6 × 30 s, 5 × 1 min, 5 × 2 min, and 2 × 5 min). Maximum activity concentrations (Bq/ml) of volume of interests over tumors and plasma in descending aorta were obtained over time frames. Kinetic parameters were estimated using in-house developed software with the two-tissue three-compartment irreversible model (2TCM) (K, k, k, and K; k = 0) and Patlak model (K) based on different acquisition durations (T) (10, 12, 14, 16, 20, 25, and 30 min, separately). Different linear regression onset time (T) points (1, 2, 3, 4, and 5 min) were applied in Patlak analysis. K of the 30-min data set was taken as the gold standard for comparison. Pearson product-moment correlation coefficient (R) of 0.9 was chosen as a limit for the correlation.
RESULTS
The correlation of kinetic parameters between the gold standard and the abbreviated dynamic data series increased with longer T from 10 to 30 min. k and k using 2TCM and K using Patlak model revealed poor correlations for dynamic PET with T ≤ 14 min (k: R = 0.84, 0.85, 0.86; k: R = 0.67, 0.67, 0.67; K: R = 0.72, 0.78, 0.87 at T = 10, 12, and 14 min, respectively). Excellent correlations were shown for all kinetic parameters when T ≥ 16 min regardless of the kinetic model and T value (R > 0.9).
CONCLUSIONS
This study indicates that a 16-min dynamic PET acquisition appears to be sufficient to provide accurate [F]FLT kinetics to quantitatively assess the proliferation in breast cancer lesions.
目的
定量评估 3'-脱氧-3'-[F]氟代胸苷([F]FLT)正电子发射断层扫描(PET)动态采集的最小扫描时间，以准确评估乳腺癌肿瘤的增殖情况。
方法
在一项治疗干预试验中，对 8 名乳腺癌患者的 26 个乳腺癌肿瘤进行了分析，这些肿瘤来自于 30 分钟的动态[F]FLT-PET 采集。PET/CT 在 Gemini TF 64 系统（飞利浦医疗保健公司）上采集，并重建为 26 个帧（8×15s、6×30s、5×1min、5×2min 和 2×5min）。通过时间帧获得肿瘤和降主动脉血浆中感兴趣区域的最大放射性浓度（Bq/ml）。使用内部开发的软件，基于不同的采集时间（T）（分别为 10、12、14、16、20、25 和 30 分钟），使用双组织三室不可逆模型（2TCM）（K、k、k 和 K；k=0）和 Patlak 模型（K）估算动力学参数。在 Patlak 分析中，应用了不同的线性回归起始时间（T）点（1、2、3、4 和 5 分钟）。将 30 分钟数据集的 K 作为比较的金标准。选择 Pearson 乘积矩相关系数（R）为 0.9 作为相关的限制。
结果
金标准与缩短的动态数据序列之间的动力学参数相关性随着 T 从 10 分钟增加到 30 分钟而增加。使用 2TCM 的 k 和 k 以及 Patlak 模型的 K 在 T≤14 分钟的动态 PET 中显示出较差的相关性（k：R=0.84、0.85、0.86；k：R=0.67、0.67、0.67；K：R=0.72、0.78、0.87 在 T=10、12 和 14 分钟时）。当 T≥16 分钟时，无论动力学模型和 T 值如何，所有动力学参数均显示出极好的相关性（R>0.9）。
结论
本研究表明，16 分钟的动态 PET 采集似乎足以提供准确的[F]FLT 动力学信息，以定量评估乳腺癌病变的增殖情况。
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