测量中性粒细胞杀菌活性。

Measuring Neutrophil Bactericidal Activity.

作者信息

Malcolm Kenneth C

机构信息

Department of Medicine, National Jewish Health, Denver, CO, USA.

出版信息

Methods Mol Biol. 2018;1809:139-144. doi: 10.1007/978-1-4939-8570-8_12.

DOI:10.1007/978-1-4939-8570-8_12

PMID:29987789

Abstract

The best-known role of neutrophils is control of pathogen growth. Neutrophils contain and kill pathogens through a variety of antimicrobial activities. Regardless of the mechanism, the ability to kill pathogens is a vital outcome. This chapter describes a method to measure the in vitro bactericidal activity of isolated neutrophils as the endpoint of converging innate immune functions.

摘要

中性粒细胞最广为人知的作用是控制病原体生长。中性粒细胞通过多种抗菌活性来抑制并杀灭病原体。无论其机制如何，杀灭病原体的能力都是一个至关重要的结果。本章介绍一种将分离出的中性粒细胞的体外杀菌活性作为固有免疫功能汇聚终点来进行测量的方法。