Siegel M L, Horwitz R, Morris T D, Di Venere R M, Siden E J
Eur J Immunol. 1985 Nov;15(11):1136-41. doi: 10.1002/eji.1830151113.
Abelson murine leukemia virus was used to transform cells of the midgestation embryonic placenta. The frequency of transformed foci in semisolid agarose was highest when cells were isolated at 10 days of gestation and cell lines could be established in liquid culture. The continuous cell lines express characteristics of cultured mast cells, including surface antigens which are shared with lymphocytes and mononuclear phagocytes. These results imply a relationship between the transforming gene product and the mast cell growth factor interleukin 3.
阿贝尔逊鼠白血病病毒被用于转化妊娠中期胚胎胎盘的细胞。当在妊娠第10天分离细胞时，半固体琼脂糖中转化灶的频率最高，并且可以在液体培养中建立细胞系。这些连续细胞系表现出培养的肥大细胞的特征，包括与淋巴细胞和单核吞噬细胞共有的表面抗原。这些结果暗示了转化基因产物与肥大细胞生长因子白细胞介素3之间的关系。
