Amano F, Nishijima M, Akagawa K, Akamatsu Y
FEBS Lett. 1985 Nov 18;192(2):263-6. doi: 10.1016/0014-5793(85)80121-6.
The effects of a monosaccharide precursor of Escherichia coli lipid A (lipid X) on murine macrophages were studied. Lipid X is a diacylglucosamine 1-phosphate bearing beta-hydroxymyristoyl groups at positions 2 and 3. Lipid X, as well as lipopolysaccharide and lipid A, enhanced O2- generation in mouse peritoneal macrophages and a macrophage-like cell line, J774.1, and further induced the tumor-cytotoxic activity of peritoneal macrophages. Elimination of a 1-phosphate or 3-O-beta-hydroxymyristoyl groups are essential for the elevated O2- generation and induction of tumoricidal activity due to lipid X.
研究了大肠杆菌脂多糖A（脂质X）的单糖前体对小鼠巨噬细胞的影响。脂质X是一种在2位和3位带有β-羟基肉豆蔻酰基的二酰基葡糖胺1-磷酸。脂质X以及脂多糖和脂质A可增强小鼠腹腔巨噬细胞和巨噬细胞样细胞系J774.1中的超氧阴离子（O₂⁻）生成，并进一步诱导腹腔巨噬细胞的肿瘤细胞毒性活性。去除1-磷酸或3-O-β-羟基肉豆蔻酰基对于脂质X引起的O₂⁻生成增加和杀肿瘤活性的诱导至关重要。
