Rigamonti S, Bettschart-Wolfensberger R, Schwarz A, Nussbaumer I
Salina Vetteam, Rheinfelden.
Departement für klinische Diagnostik und Services, Abteilung Anästhesiologie, Vetsuisse-Fakultät, Universität Zürich.
Schweiz Arch Tierheilkd. 2018 Jul;160(7-8):469-474. doi: 10.17236/sat00170.
The aim of this study was to find an intramuscularly (IM) injectable anaesthetic combination for 8 to 14-days old piglets, that guarantees a calm induction and sufficient quality of anaesthesia without excitations with a maximum of two hours long lasting recovery. In preliminary dose finding trials, different combinations of -ketamine, azaperone and romifidine were compared. A constant dose of 0.2 mg/kg of butorphanol was added to each combination and all piglets received 0.4 mg/kg meloxicam. Subsequently a dosage algorithm for the main trial was developed. In case of insufficient analgesia, lidocaine 2% (0.25 ml) was injected intratesticular. If two piglets showed an insufficient anaesthetic induction phase, depth of anaesthesia or recovery, the next dosage in the algorithm was tried. With the combination of 3 mg/kg azaperone, 0.2 mg/kg romifidine, 15 mg/kg ketamine and 0.2 mg/kg butorphanol the requirement of a smooth anaesthesia induction, sufficient anaesthesia and a recovery without excitation was fulfilled but the recovery lasted more than 120 minutes.
本研究的目的是为8至14日龄仔猪找到一种肌肉注射的麻醉合剂,确保诱导过程平稳,麻醉质量足够,无兴奋现象,且最长恢复时间为两小时。在初步的剂量探索试验中,比较了氯胺酮、阿扎哌隆和罗米定的不同组合。每种组合中均添加0.2 mg/kg的恒定剂量布托啡诺,所有仔猪均接受0.4 mg/kg美洛昔康。随后制定了主要试验的剂量算法。若镇痛不足,则睾丸内注射2%利多卡因(0.25 ml)。若有两只仔猪的麻醉诱导期、麻醉深度或恢复情况不足,则尝试算法中的下一个剂量。3 mg/kg阿扎哌隆、0.2 mg/kg罗米定、15 mg/kg氯胺酮和0.2 mg/kg布托啡诺的组合满足了平稳麻醉诱导、足够麻醉和无兴奋恢复的要求,但恢复时间超过了120分钟。