基于 MUC1 的肿瘤靶向和端粒酶控制的 DOX 释放的多功能纳米探针用于诊断和治疗的荧光原位监测
In situ fluorescence monitoring of diagnosis and treatment: a versatile nanoprobe combining tumor targeting based on MUC1 and controllable DOX release by telomerase.
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014 Shandong, P. R. China.
出版信息
Chem Commun (Camb). 2018 Jul 19;54(59):8277-8280. doi: 10.1039/c8cc05052j.
We have constructed versatile drug-loaded nanoprobes capable of responding to both MUC1 and telomerase and achieving intracellular drug release. Besides, the synthesized drug-loaded nanoprobes can realize the in situ imaging observation of the whole process of nanoprobes targeting the tumor cell membrane, the transmembrane entering the cytoplasm and the release of DOX into the cell nucleus.
我们构建了多功能载药纳米探针，能够同时响应 MUC1 和端粒酶，并实现细胞内药物释放。此外，所合成的载药纳米探针能够实现纳米探针靶向肿瘤细胞膜、跨膜进入细胞质以及 DOX 释放进入细胞核的整个过程的原位成像观察。
Zotero 插件