Hamm Wolfgang, von Stülpnagel Lukas, Klemm Mathias, Baylacher Monika, Rizas Konstantinos D, Bauer Axel, Brunner Stefan
1 Medical Department I, Cardiology, Ludwig-Maximilian University Munich , Munich, Germany .
2 German Cardiovascular Research Center (DZHK) , Partner Site: Munich Heart Alliance, Munich, Germany .
High Alt Med Biol. 2018 Sep;19(3):299-302. doi: 10.1089/ham.2018.0041. Epub 2018 Jul 10.
Hamm, Wolfgang, Lukas von Stülpnagel, Mathias Klemm, Monika Baylacher, Konstantinos D. Rizas, Axel Bauer, and Stefan Brunner. Deceleration capacity of heart rate after acute altitude exposure. High Alt Med Biol 19:299-302, 2018.
The autonomic nervous system plays a crucial role in adaptive changes after high-altitude exposure. Deceleration capacity (DC) of heart rate is an advanced marker of heart rate variability (HRV) that predominantly reflects the vagal activity of the cardiac autonomic nervous system. The impact of high-altitude exposure on DC has not been investigated yet.
In eight healthy individuals we performed a high-resolution digital 30-min electrocardiography in Frank leads configuration at baseline (521 m altitude), immediately after ascent to the Environmental Research Station Schneefernerhaus (UFS) at Zugspitze (2650 m altitude) and after a sojourn of 24 hours at this altitude. DC of heart rate was assessed using customized software. In addition, standard parameters of HRV were assessed.
DC decreased significantly from 10.2 ± 0.8 ms to 8.9 ± 1.0 ms (p < 0.05) after acute altitude exposure. After a sojourn of 24 hours at high altitude, DC remained low at 8.6 ± 1.2 ms. There were no significant changes in standard parameters of HRV.
Our findings show for the first time a decrease of DC of heart rate providing a novel insight into the dysbalance of autonomic nervous system at high altitude.
哈姆，沃尔夫冈；卢卡斯·冯·施图尔普纳格尔；马蒂亚斯·克莱姆；莫妮卡·贝拉克尔；康斯坦丁诺斯·D·里扎斯；阿克塞尔·鲍尔；斯特凡·布鲁纳。急性高原暴露后心率的减速能力。《高海拔医学与生物学》19:299 - 302，2018年。
自主神经系统在高原暴露后的适应性变化中起关键作用。心率减速能力（DC）是心率变异性（HRV）的一个高级指标，主要反映心脏自主神经系统的迷走神经活动。高原暴露对DC的影响尚未得到研究。
我们对8名健康个体在基线（海拔521米）、刚登上楚格峰的环境研究站雪费尔纳豪斯（UFS，海拔2650米）后以及在该海拔停留24小时后，以弗兰克导联配置进行了一次30分钟的高分辨率数字心电图检查。使用定制软件评估心率的DC。此外，还评估了HRV的标准参数。
急性高原暴露后，DC从10.2±0.8毫秒显著降至8.9±1.0毫秒（p<0.05）。在高海拔停留24小时后，DC仍维持在较低水平，为8.6±1.2毫秒。HRV的标准参数没有显著变化（差异无统计学意义）。
我们的研究结果首次表明心率DC降低，为高原自主神经系统失衡提供了新的见解。
