Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City, 04510, Mexico; Department of Food and Biotechnology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City, 04510, Mexico.
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City, 04510, Mexico.
Food Chem Toxicol. 2018 Oct;120:230-242. doi: 10.1016/j.fct.2018.07.018. Epub 2018 Jul 7.
Cancer is a relevant public health problem that represents the second leading cause of global death. In this regard, cisplatin is a highly effective antineoplastic drug used in treatment of several types of cancer, such as head and neck, testicular, ovarian, gastric, lung and breast cancer. Nevertheless, treatment with this compound leads to nephrotoxicity, which limits its use. Oxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. Further, limitations of animal models used in these studies are discussed. Additionally, clinical studies on the protective effect of these antioxidants, as well as future directions for these kind of trials are also considered.
癌症是一个重大的公共卫生问题，是全球第二大死亡原因。在这方面，顺铂是一种高度有效的抗肿瘤药物，用于治疗多种癌症，如头颈部、睾丸、卵巢、胃、肺和乳腺癌。然而，这种化合物的治疗会导致肾毒性，从而限制了它的使用。氧化应激在顺铂引起的肾损伤中起着关键作用，已有报道称，几种膳食抗氧化剂可以改善这种副作用。本文总结了这些抗氧化剂在顺铂诱导的肾毒性中的保护作用的相关研究结果。此外，还讨论了这些研究中使用的动物模型的局限性。此外，还考虑了这些抗氧化剂的保护作用的临床研究以及这类试验的未来方向。
