Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, PR China; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, PR China.
Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, PR China.
Biomed Pharmacother. 2018 Oct;106:672-677. doi: 10.1016/j.biopha.2018.07.006. Epub 2018 Jul 11.
Krüppel-like factors (KLFs) are transcription factors containing three different C2H2-type zinc finger domains in their carboxy-terminal regions which have been identified to play important roles in a variety of cancers. However, little is known about KLF15 in lung adenocarcinoma (LAUD). Our study demonstrated that the expression levels of KLF15 were observably down-regulated in LAUD tissues compared to paired adjacent normal tissues. LUAD patients with low expression levels of KLF15 have worse prognosis than those with high expression levels of KLF15. KLF15 could suppress cell growth, which was partly via up-regulating CDKN1 A/p21 and CDKN2A/p15. Our findings suggested that KLF15 showed a significant role in LAUD progression and may shed light on a promising novel therapeutic target for blocking progression of LAUD.
Krüppel 样因子（KLFs）是一类转录因子，其羧基末端区域含有三个不同的 C2H2 型锌指结构域，已被证实其在多种癌症中发挥着重要作用。然而，关于肺腺癌（LAUD）中的 KLF15 却知之甚少。我们的研究表明，与配对的癌旁正常组织相比，KLF15 的表达水平在 LAUD 组织中明显下调。KLF15 低表达的 LUAD 患者的预后比 KLF15 高表达的患者差。KLF15 可以抑制细胞生长，这部分是通过上调 CDKN1A/p21 和 CDKN2A/p15 实现的。我们的研究结果表明，KLF15 在 LAUD 进展中起着显著作用，可能为阻止 LAUD 进展提供有前途的新的治疗靶点。
