供体 CYP3A5 和 ABCB1 多态性对肾移植后临床结局无影响。

CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation.

机构信息

Department of Pharmacy, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, PR China.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

出版信息

Pharmacogenomics. 2018 Jul 1;19(11):895-903. doi: 10.2217/pgs-2018-0066. Epub 2018 Jul 11.

DOI:10.2217/pgs-2018-0066

PMID:29991328

Abstract

AIM

To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients.

METHODS

The CYP3A5 6986A>G and ABCB1 3435C>T polymorphisms were determined in 237 recipients and donors.

RESULTS

There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype. The donor ABCB1 3435C>T polymorphism was associated with estimated glomerular filtration rate on day 7 and month 1. The combined donor-recipient ABCB1 genotype (3435C>T polymorphism) was significantly related with estimated glomerular filtration rate on day 3 and 7 in univariate analysis. However, these differences were no longer statistically significant in multivariate analysis.

CONCLUSION

A genetic analysis of ABCB1 and CYP3A5 of kidney transplant donors is not helpful to improve renal transplant outcomes.

摘要

目的

探讨供体 CYP3A5 和 ABCB1 多态性与肾移植受者他克莫司（Tac）诱导的肾毒性和肾功能之间的关系。

方法

在 237 名受者和供者中确定了 CYP3A5 6986A>G 和 ABCB1 3435C>T 多态性。

结果

Tac 相关肾毒性与供体 CYP3A5 和 ABCB1 基因型之间无显著相关性。供体 ABCB1 3435C>T 多态性与第 7 天和第 1 个月的估计肾小球滤过率（eGFR）有关。单变量分析中，供体-受者 ABCB1 基因型（3435C>T 多态性）与第 3 天和第 7 天的 eGFR 显著相关。然而，在多变量分析中，这些差异不再具有统计学意义。