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[精索脂肪肉瘤。两例报告及文献复习。]

[Spermatic cord liposarcoma. Report of two cases and bibliographic review.].

作者信息

Valverde Martínez Sebastián, Salcedo Mercado Waleska, Grinard de León Edwin, Polo López Carlos, Gallego Matey Angel, Gómez Tejeda Luis Miguel

机构信息

Servicio de Urología. Complejo Asistencial de Avila. Avila. España.

Servicio de Anatomía Patológica. Complejo Asistencial de Avila. Avila. España.

出版信息

Arch Esp Urol. 2018 Jul;71(6):549-554.

Abstract

OBJECTIVE

We report two cases of patients diagnosed of paratesticular liposarcoma and perform a literature review of this rare entity. Our aim is to clarify its clinical and therapeutic characteristics.

METHODS

Retrospective review of the medical records of two patients diagnosed of liposarcoma of the spermatic cord.

RESULTS

Case 1: 65 year old male, presented a left large scrotal mass of 20 × 14 × 11 cm. He underwent radical orchiectomy. Pathology reported a well differentiated spermatic cord liposarcoma. After one year of follow-up the patient was asymptomatic and there was no evidence of local recurrence. Case 2: A 90 year old man, with past medical history of right orchiectomy for well-differentiated cord liposarcoma 11 years before, and excision of recurrence 7 years ago. On follow up he presented a new 20 × 14 × 11 cm inguinal tumor recurrence. We performed excision of the mass, which was reported by pathology as well differentiated spermatic cord liposarcoma. Ten months after surgery the patient was asymptomatic without recurrence.

CONCLUSIONS

Liposarcoma is a very rare entity and its diagnosis is based on the pathological findings. It is therefore difficult to establish the guidelines for treatment, prognosis and differential diagnosis. As in liposarcomas in other sites, the histological type and grade of the lesion are useful for the prognosis. Radical inguinal orchiectomy and resection of the tumor with a negative microscopic margin is the recommended treatment for liposarcoma of the spermatic cord. It has not been demonstrated the efficacy of adjuvant treatments such as chemotherapy or radiotherapy, except in specific situations. The natural history of disease is slow and it has low mortality, but high recurrence rate, so a long-term monitoring is necessary.

摘要

目的

我们报告两例诊断为睾丸旁脂肪肉瘤的患者,并对这一罕见疾病进行文献综述。我们的目的是阐明其临床和治疗特征。

方法

回顾性分析两名诊断为精索脂肪肉瘤患者的病历。

结果

病例1:一名65岁男性,左侧阴囊有一个20×14×11 cm的大肿块。他接受了根治性睾丸切除术。病理报告为高分化精索脂肪肉瘤。随访一年后,患者无症状,无局部复发迹象。病例2:一名90岁男性,11年前因高分化精索脂肪肉瘤行右侧睾丸切除术,7年前切除复发灶。随访时,他出现一个新的20×14×11 cm腹股沟肿瘤复发。我们切除了肿块,病理报告为高分化精索脂肪肉瘤。手术后十个月,患者无症状,无复发。

结论

脂肪肉瘤是一种非常罕见的疾病,其诊断基于病理结果。因此,很难制定治疗、预后和鉴别诊断的指南。与其他部位的脂肪肉瘤一样,病变的组织学类型和分级对预后有帮助。根治性腹股沟睾丸切除术和肿瘤切除且切缘显微镜下阴性是精索脂肪肉瘤的推荐治疗方法。除特殊情况外,尚未证明化疗或放疗等辅助治疗的疗效。该病的自然病程缓慢,死亡率低,但复发率高,因此需要长期监测。

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