Vallianou Natalia G, Mitesh Shah, Gkogkou Agathoniki, Geladari Eleni
Evangelismos General Hospital, 45-47 Ipsilantou str, Athens, Greece.
Curr Cardiol Rev. 2019;15(1):55-63. doi: 10.2174/1573403X14666180711124825.
Chronic Kidney Disease is a growing health burden world wide. Traditional and mutual risk factors between CVD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, family history and male gender. In this review, we will focus on whether or not early CKD is an important risk factor for the presence, severity and progression of CVD. Specifically, we will examine both traditional and novel risk factors of both CKD and CVD and how they relate to each other.
We will also assess if early treatment of CKD, intensive compared to standard, has an important effect on the halt of the development of CKD as well as CVD. Insights into the pathogenesis and early recognition of CKD as well as the importance of novel kidney biomarkers will be pointed out. Also, common pathogenetic mechanisms between CKD and CVD will be discussed.
慢性肾脏病在全球范围内对健康造成的负担日益加重。心血管疾病(CVD)和慢性肾脏病的传统及共同危险因素包括年龄、高血压、糖尿病、血脂异常、吸烟、家族史和男性性别。在本综述中,我们将聚焦于早期慢性肾脏病是否是心血管疾病发生、严重程度及进展的重要危险因素。具体而言,我们将研究慢性肾脏病和心血管疾病的传统及新型危险因素,以及它们之间的相互关系。
我们还将评估与标准治疗相比,慢性肾脏病的早期强化治疗对阻止慢性肾脏病以及心血管疾病发展是否具有重要作用。将指出对慢性肾脏病发病机制及早期识别的见解,以及新型肾脏生物标志物的重要性。此外,还将讨论慢性肾脏病和心血管疾病之间的共同发病机制。