因子 XII 在炎症和伤口愈合中的作用。
Factor XII in inflammation and wound healing.
机构信息
Department of Medicine, Louis Stokes Veterans Administration Medical Center.
Department of Medicine, Hematology and Oncology Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
出版信息
Curr Opin Hematol. 2018 Sep;25(5):403-409. doi: 10.1097/MOH.0000000000000450.
PURPOSE OF REVIEW
This review describes the contribution of coagulation factor XII (FXII) in sterile inflammation and wound healing, focusing on recently identified roles for zymogen FXII in neutrophil functions.
RECENT FINDINGS
Recent studies have identified an important role for FXII in neutrophil trafficking. In particular, following neutrophil activation, autocrine FXII signals through the urokinase plasminogen activator receptor (uPAR) on the neutrophil surface to upregulate neutrophil functions. The sum of these activities leads to neutrophil adhesion, chemotaxis, and neutrophil extracellular (NET) formation. Downregulating FXII-mediated signaling in neutrophils is associated with improved wound healing.
SUMMARY
These recent findings show the sophisticated role of FXII in vivo and create new opportunities for research on the treatment of chronic inflammatory diseases.
目的综述
本文描述了凝血因子 XII（FXII）在无菌性炎症和伤口愈合中的作用，重点介绍了最近发现的 FXII 酶原在中性粒细胞功能中的作用。
最近的发现
最近的研究确定了 FXII 在中性粒细胞迁移中的重要作用。特别是，中性粒细胞激活后，内源性 FXII 通过中性粒细胞表面的尿激酶型纤溶酶原激活物受体（uPAR）发出信号，上调中性粒细胞功能。这些活动的总和导致中性粒细胞黏附、趋化和中性粒细胞胞外网状（NET）形成。下调中性粒细胞中 FXII 介导的信号转导与改善伤口愈合有关。
总结
这些新发现表明 FXII 在体内具有复杂的作用，并为慢性炎症性疾病的治疗研究创造了新的机会。
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