Hu Huizhen, Shen Yuqing
Bing Du Xue Bao. 2016 Jul;32(4):495-500.
Respiratory syndrome coronavirus in the Middle East (MERS-Co V) has caused wide attention since it was discovered, and the design of effective vaccines for MERS-Co V becomes a hot area at present. Therefore, this review is aimed at novel research progress of the recombinant vaccine for MERS-Co V, including selection and improvement of animal model for vaccine test,construction and optimization of recombinant subunit vaccine, attempts at recombinant live vector vaccine based on varies of vectors, as well as the advantages of pseudovirus. In conclusion, we make a summary about the novel research progress of the recombinant vaccine for MERS-Co V and a promising prospect of its development in terms of both safety and effectiveness verification in the future will be demonstrated.
中东呼吸综合征冠状病毒（MERS-CoV）自被发现以来引起了广泛关注，目前针对MERS-CoV的有效疫苗设计成为一个热门领域。因此，本综述旨在探讨MERS-CoV重组疫苗的最新研究进展，包括疫苗试验动物模型的选择与改进、重组亚单位疫苗的构建与优化、基于多种载体的重组活载体疫苗的尝试以及假病毒的优势。总之，我们对MERS-CoV重组疫苗的最新研究进展进行了总结，并展示了其在未来安全性和有效性验证方面发展的广阔前景。
