Δ9-四氢大麻酚在单侧黑质损伤的大鼠中引发同侧转圈行为。
delta 9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion.
作者信息
Sakurai Y, Ohta H, Shimazoe T, Kataoka Y, Fujiwara M, Ueki S
出版信息
Life Sci. 1985 Dec 9;37(23):2181-5. doi: 10.1016/0024-3205(85)90569-7.
PMID:2999542
Abstract
The present study was designed to examine the influence of delta 9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxy-dopamine. THC-induced ipsilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.
摘要
本研究旨在利用转圈行为来检测δ9 - 四氢大麻酚（THC）对中枢多巴胺能系统的影响。腹腔注射5mg/kg的THC可使经6 - 羟基多巴胺造成单侧黑质损伤的大鼠产生向患侧转圈行为。0.2mg/kg的氟哌啶醇可完全拮抗THC诱导的向患侧转圈行为。这些结果表明，THC可能对黑质纹状体多巴胺能神经元产生突触前刺激作用。
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