2i，还是非 2i：Nanog 阴性小鼠胚胎干细胞的独白。
2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells.
机构信息
Epigenetics of Stem Cells, Department of Developmental & Stem Cell Biology, Institut Pasteur, CNRS UMR 3738, 25 rue du docteur Roux, 75015 Paris, France.
出版信息
Stem Cell Reports. 2018 Jul 10;11(1):1-3. doi: 10.1016/j.stemcr.2018.06.017.
In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures.
在本期《Stem Cell Reports》中，Hastreiter 等人（2018）利用连续延时成像技术研究了抑制 GSK3b 和 MEK/ERK（2i）如何导致转录因子 Nanog 的均匀表达。他们表明，Nanog 表达的诱导和对低水平表达 Nanog 细胞的选择都有助于 2i 培养物的均匀外观。
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