Wang S, Zhang W, Zhang F, Qian Z, Wang L F, Ren L J, Yang S
Department of Gastroenterology, the Third Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China.
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China.
Zhonghua Gan Zang Bing Za Zhi. 2018 May 20;26(5):342-346. doi: 10.3760/cma.j.issn.1007-3418.2018.05.006.
To investigate the predictive value of transient elastography (FibroScan), aspartate aminotransferase-to-platelet ratio index (APRI) in the detection of esophagogastric varices in patients with liver cirrhosis. 236 patients with liver cirrhosis who met the criteria were selected. All patients underwent gastroscopy. According to the degree of esophagogastric varices, patients were divided into four groups: none, mild, moderate, and severe. The patient's liver stiffness (LSM) and aspartate aminotransferase- to-platelet ratio index (APRI) were measured within 3 days of gastroscopy. One-way analysis of variance was used to compare multi-group data. The ROC curves of LSM, APRI, LSM+APRI in patients with liver cirrhosis with esophageal varices were plotted and their area under the ROC curve (AUC) were compared. The area under the ROC curve of LSM, APRI, LSM + APRI in patients with mild esophagogastric varices were 0.856, 0.900, and 0.906, respectively; moderate esophagogastric varices were 0.857, 0.924, and 0.923 respectively; and severe esophagogastric varices were 0.801, 0.903, and 0.901, respectively. APRI and LSM+APRI have better predictive value for patients with cirrhosis who have esophagogastric varices.
为探讨瞬时弹性成像（FibroScan）、天冬氨酸氨基转移酶与血小板比值指数（APRI）在肝硬化患者食管胃静脉曲张检测中的预测价值。选取236例符合标准的肝硬化患者。所有患者均接受胃镜检查。根据食管胃静脉曲张程度，将患者分为四组：无、轻度、中度和重度。在胃镜检查后3天内测量患者的肝脏硬度（LSM）和天冬氨酸氨基转移酶与血小板比值指数（APRI）。采用单因素方差分析比较多组数据。绘制肝硬化合并食管静脉曲张患者LSM、APRI、LSM+APRI的ROC曲线，并比较其曲线下面积（AUC）。轻度食管胃静脉曲张患者LSM、APRI、LSM+APRI的曲线下面积分别为0.856、0.900和0.906；中度食管胃静脉曲张患者分别为0.857、0.924和0.923；重度食管胃静脉曲张患者分别为0.801、0.903和0.901。APRI和LSM+APRI对肝硬化合并食管胃静脉曲张患者具有较好的预测价值。
