[Polymorphisms of mTORC1 genes and risk of primary colorectal adenocarcinoma in Chinese populations].

To study the associations between variants of mTORC1 of PI3K/AKT/mTOR pathway and colorectal cancer. In this hospital-based case-control study, at the First Affiliated Hospital, Xinjiang Medical University from 2000 to 2013, 665 primary colorectal cancer cases and 695 cancer-free controls were genotyped at 10 potentially functional single nucleotide polymorphism (SNPs) loci of mTORC1 (mTOR: rs1034528, rs2295080; Raptor: rs1062935, rs3751934; mLST8: rs3160, rs26865; DEPTOR: rs2271900, rs4871827; AKT1S1: rs2290774, rs2353005) to assess their associations with risk of colorectal cancer by Logistic regression analysis. In single-locus analysis, found a significantly decreased risk of colorectal cancer associated with mLST8 rs26865 by recessive genetic model, especially in populations of ≤68 years of age (=0.64; 95%=0.43-0.96, =0.031), female (=0.61; 95%=0.38-0.99, =0.046), non-smoking (=0.55; 95%=0.35-0.87, =0.010). mTOR rs1034528 CC genotypes were associated with higher risk of colorectal cancer in >68-year-old populations (=3.34; 95%=1.12-9.91, =0.030). Raptor rs3751934 CA/AA genotypes were associated with lower colorectal cancer risk in population of body mass index(BMI)>25 kg/m(2) (=0.68; 95%=0.47-0.98, =0.038); and AKT1S1 rs2290774 CC genotypes were associated with lower colorectal cancer risk in non-smoking population (=0.67; 95%=0.45-0.99, =0.048). Furthermore, found that populations carrying more than two low-risk genotypes were associated with lower colorectal cancer risk, compared with that of populations carrying less than two low-risk genotypes (=0.74, 95%=0.58-0.95, =0.017), especially in population of ≤68 years of age, male and BMI>25 kg/m(2,) and non-smoking. SNPs of mTORC1-related genes individually or jointly contribute to colorectal cancer susceptibility in Chinese. Further studies of larger cohorts are needed to validate the findings.