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Effects of gamma-vinyl-GABA on the human electroencephalogram.

作者信息

Hammond E J, Wilder B J

出版信息

Neuropharmacology. 1985 Oct;24(10):975-84. doi: 10.1016/0028-3908(85)90125-x.

DOI:10.1016/0028-3908(85)90125-x
PMID:2999635
Abstract

Gamma-vinyl-GABA (GVG) is a new anticonvulsant drug that significantly raises the level of the gamma-aminobutyric acid in the brain (GABA). The effects of gamma-vinyl-GABA on the human electroencephalogram were studied to assess the role of GABAergic mechanisms on electrocortical activity. Serial EEGs were recorded in 15 epileptic patients undergoing a controlled clinical trial of gamma-vinyl-GABA. The effects of gamma-vinyl-GABA on alpha, beta, or theta activity, sleep spindles and epileptiform activity were studied. No changes could be detected in any of the intrinsic brain rhythms. Three patients showed a mild amelioration of epileptiform activity; no increase in epileptiform activity was seen.

摘要

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