Dimpfel W
Neuropsychobiology. 1985;14(1):42-52. doi: 10.1159/000118200.
Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with a down-regulating effect on dopaminergic impulse activity produced a significant diminution of the response, whereas compounds enhancing dopaminergic impulse flow produced an increase of the signal amplitude. The results are discussed in terms of the usefulness of the evoked potential as a screening procedure for monitoring dopaminergic impulse flow during the evaluation of new drugs against schizophrenia.
在两个多巴胺能靶区研究了从中脑电诱发的场电位变化。跟踪静脉注射各种影响中枢多巴胺能传递的化合物所诱导的前额叶皮层和纹状体反应的调制情况。一般来说，对多巴胺能冲动活动具有下调作用的药物会使反应显著减弱，而增强多巴胺能冲动流的化合物会使信号幅度增加。根据诱发电位在评估抗精神分裂症新药过程中作为监测多巴胺能冲动流的筛选程序的有用性对结果进行了讨论。
