GRP78 Is a Targetable Receptor on Cancer and Stromal Cells.
作者信息
Araujo Nathalia, Hebbar Nikhil, Rangnekar Vivek M
机构信息
Departments of Toxicology and Cancer Biology, University of Kentucky, United States.
St. Jude Children's Research Hospital, Memphis, TN, United States.
出版信息
EBioMedicine. 2018 Jul;33:2-3. doi: 10.1016/j.ebiom.2018.06.030. Epub 2018 Jul 8.
Abstract
摘要
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EBioMedicine. 2018 Jul;33:22-32. doi: 10.1016/j.ebiom.2018.06.004. Epub 2018 Jun 12.
2
Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.白血病和淋巴瘤中膜相关GRP78的治疗靶点：BMTP-78在啮齿动物和灵长类动物中的体外临床前疗效及正式毒性研究
Pharmacogenomics J. 2018 May 22;18(3):436-443. doi: 10.1038/tpj.2017.46. Epub 2017 Dec 5.
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Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction.肌动蛋白结合蛋白靶向细胞表面的葡萄糖调节蛋白78，并通过诱导线粒体功能障碍触发细胞凋亡。
Cell Death Differ. 2014 May;21(5):797-810. doi: 10.1038/cdd.2014.3. Epub 2014 Jan 24.
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Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.针对细胞表面 GRP78 的单克隆抗体作为一种新型药物，可抑制 PI3K/AKT 信号通路、肿瘤生长和转移。
Clin Cancer Res. 2013 Dec 15;19(24):6802-11. doi: 10.1158/1078-0432.CCR-13-1106. Epub 2013 Sep 18.
5
Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4.细胞外 PAR-4 介导的癌症细胞凋亡抵抗的新机制。
Cancer Res. 2013 Jan 15;73(2):1011-9. doi: 10.1158/0008-5472.CAN-12-3212. Epub 2012 Nov 30.
6
ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK.内质网应激通过整合基础 IKK 活性、IRE1 和 PERK 的功能来激活 NF-κB。
PLoS One. 2012;7(10):e45078. doi: 10.1371/journal.pone.0045078. Epub 2012 Oct 26.
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Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting.超越内质网：细胞活力、信号转导和治疗靶点中的非典型 GRP78。
Biochem J. 2011 Mar 1;434(2):181-8. doi: 10.1042/BJ20101569.
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