促肾上腺皮质激素1-24对自发性高血压（SH）大鼠和正常血压（WKY）大鼠主动脉条中去甲肾上腺素收缩反应的增强作用。

ACTH 1-24-induced potentiation of norepinephrine contractile responses in aortic strips from spontaneously hypertensive (SH) and normotensive (WKY) rats.

作者信息

Vergona R A, Strand F L, Cohen M R

出版信息

Peptides. 1985 Jul-Aug;6(4):581-4. doi: 10.1016/0196-9781(85)90156-1.

Abstract

Norepinephrine (NE)-induced contractile responses were less in aortic strips from SH compared to WKY rats. ACTH 1-24 potentiated NE responses in both SH and WKY aortic strips. This effect was more potent in SH aortic strips. NE-induced contractions in SH aortic strips were less sensitive to changes in external Ca2+ levels than were those of WKY aortic strips. ACTH 1-24 did not potentiate NE responses under low external Ca2+ conditions in SH aortic strips or under high external Ca2+ conditions in WKY aortic strips. The greater sensitivity of NE responses following ACTH 1-24 in SH aortic strips may imply that this peptide is modulating a mechanism related to an impaired contractility and that Ca2+ plays a key role in the observed effects.

摘要

与WKY大鼠相比，SH大鼠主动脉条中去甲肾上腺素（NE）诱导的收缩反应较弱。促肾上腺皮质激素1-24（ACTH 1-24）增强了SH和WKY主动脉条中NE的反应。这种作用在SH主动脉条中更强。SH主动脉条中NE诱导的收缩对外界Ca2+水平变化的敏感性低于WKY主动脉条。在低外界Ca2+条件下的SH主动脉条或高外界Ca2+条件下的WKY主动脉条中，ACTH 1-24均未增强NE反应。SH主动脉条中ACTH 1-24作用后NE反应的更高敏感性可能意味着该肽正在调节与收缩力受损相关的机制，并且Ca2+在观察到的效应中起关键作用。