Rasmussen B B
Pathol Res Pract. 1985 Oct;180(4):377-82. doi: 10.1016/S0344-0338(85)80110-2.
In a histologic reevaluation of 247 primary human mucinous breast carcinomas, 207 tumors fullfilled the criteria for further histopathological evaluation. The criteria for entrance in this survey are that at least 25% of the tumor consists of areas of extracellular mucin with small islands of solid epithelial tumor tissue floating in the mucin, and that the extracellular mucin should comprise at least 33% of the total tumor volume. The 247 carcinomas that have been further evaluated have been subclassified into two groups: "pure" mucinous breast carcinomas that consist solely of tumor tissue with extracellular mucin production (95 tumors), and "mixed" mucinous carcinomas that also contain infiltrating carcinoma without extracellular mucin (112 tumor). A significantly greater number of mixed carcinomas than pure carcinomas have an aggressive growth pattern--as defined by tumor size, adherence to overlying skin/bottom fascie, and primary axillary lymph node metastases. The histogenesis of the mucinous carcinomas is briefly discussed in relation to the present observations and the literature. The importance of clearly distinguishing between the mixed and the pure mucinous carcinomas in the diagnosis of these tumors is emphasized.
在对247例原发性人黏液性乳腺癌进行组织学重新评估时，207例肿瘤符合进一步组织病理学评估的标准。本研究纳入标准为：肿瘤至少25%由细胞外黏液区域组成，其中有小的实性上皮肿瘤组织岛漂浮在黏液中，且细胞外黏液应占肿瘤总体积的至少33%。经过进一步评估的247例癌被分为两组：“纯”黏液性乳腺癌，仅由产生细胞外黏液的肿瘤组织组成（95例肿瘤）；“混合”黏液性癌，还包含无细胞外黏液的浸润性癌（112例肿瘤）。与“纯”癌相比，“混合”癌中具有侵袭性生长模式（根据肿瘤大小、与上方皮肤/底部筋膜的粘连情况以及腋窝淋巴结转移情况定义）的数量显著更多。结合目前的观察结果和文献简要讨论了黏液性癌的组织发生。强调了在这些肿瘤的诊断中明确区分混合性和纯黏液性癌的重要性。
