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抗血管生成草药组合物Ob-X可减少人体腹部内脏脂肪：一项随机、双盲、安慰剂对照研究。

Antiangiogenic Herbal Composition Ob-X Reduces Abdominal Visceral Fat in Humans: A Randomized, Double-Blind, Placebo-Controlled Study.

作者信息

Kang Jae-Heon, Jeong In Sun, Kim Min-Young

机构信息

Inje University Seoul Paik hospital, Seoul 04551, Republic of Korea.

AngioLab, Inc., Daejeon 34016, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2018 May 28;2018:4381205. doi: 10.1155/2018/4381205. eCollection 2018.

DOI:10.1155/2018/4381205
PMID:29997675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5994586/
Abstract

Adipose tissue growth is angiogenesis-dependent, and angiogenesis inhibitors can regulate adipose tissue mass by cutting off the blood supply. We examined whether antiangiogenic herbal composition Ob-X can reduce fast-growing abdominal fat, especially visceral fat in humans by inhibiting angiogenesis. Eighty abdominally obese subjects (body mass index: 25-29.9 kg/m, waist circumference: exceeding 90 cm for males and 85 cm for females) participated in a 12-week randomized, double-blind, placebo-controlled human study to evaluate the efficacy and safety of Ob-X. 690 mg of Ob-X was administered orally twice a day. The Ob-X group showed a noticeable reduction in visceral fat of 20.5% after the 12-week treatment as compared to baseline measured by computed tomography. The change in visceral fat in the Ob-X group was statistically significant as compared to the placebo group (p = 0.0495) and 1.9 times higher than in the placebo group. Therefore, angiogenesis inhibitor Ob-X has the potential to improve obesity-related metabolic syndrome by reducing dangerous visceral fat.

摘要

脂肪组织的生长依赖于血管生成，血管生成抑制剂可通过切断血液供应来调节脂肪组织的质量。我们研究了抗血管生成草药组合物Ob-X是否能通过抑制血管生成来减少人类快速增长的腹部脂肪，尤其是内脏脂肪。80名腹部肥胖受试者（体重指数：25-29.9kg/m，腰围：男性超过90cm，女性超过85cm）参与了一项为期12周的随机、双盲、安慰剂对照人体研究，以评估Ob-X的疗效和安全性。每天口服两次690mg的Ob-X。与通过计算机断层扫描测量的基线相比，Ob-X组在12周治疗后内脏脂肪明显减少了20.5%。与安慰剂组相比，Ob-X组内脏脂肪的变化具有统计学意义（p=0.0495），且比安慰剂组高1.9倍。因此，血管生成抑制剂Ob-X有潜力通过减少危险的内脏脂肪来改善肥胖相关的代谢综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/9772dcd4d487/ECAM2018-4381205.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/5755e9a63251/ECAM2018-4381205.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/a553f49a825b/ECAM2018-4381205.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/de82a2e564ea/ECAM2018-4381205.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/9772dcd4d487/ECAM2018-4381205.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/5755e9a63251/ECAM2018-4381205.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/a553f49a825b/ECAM2018-4381205.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/de82a2e564ea/ECAM2018-4381205.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/5994586/9772dcd4d487/ECAM2018-4381205.004.jpg

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Cardiovasc Diabetol. 2015 Feb 10;14:20. doi: 10.1186/s12933-015-0184-5.
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From excess adiposity to insulin resistance: the role of free fatty acids.从肥胖到胰岛素抵抗：游离脂肪酸的作用。
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The anti-angiogenic herbal extracts Ob-X from Morus alba, Melissa officinalis, and Artemisia capillaris suppresses adipogenesis in 3T3-L1 adipocytes.白桑、香蜂草和青蒿的抗血管生成草药提取物 Ob-X 可抑制 3T3-L1 脂肪细胞的脂肪生成。
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