胃肠道间质瘤：手术及药物治疗方案的进展
Gastrointestinal stromal tumours: advances in surgical and pharmacological management options.
作者信息
Thacoor Amitabh
机构信息
School of Medicine, University of Leeds, Leeds, UK.
出版信息
J Gastrointest Oncol. 2018 Jun;9(3):573-578. doi: 10.21037/jgo.2018.01.10.
Abstract
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. The stomach is most commonly affected. Advances in immunopathology have identified a mutation in the c-KIT proto-oncogene, leading to the development of the tyrosine-kinase inhibitor Imatinib as targeted therapy for advanced disease. Surgery, however, remains the only curative treatment of resectable primary GIST. This review article aims at reviewing the management of primary GISTs, investigating recurrences, exploring the role of surgery in metastatic disease and looking into combined surgery and molecular therapy for GISTs.
摘要
胃肠道间质瘤（GISTs）是胃肠道最常见的间叶性肿瘤。最常受累的部位是胃。免疫病理学的进展已确定c-KIT原癌基因发生突变，从而促使酪氨酸激酶抑制剂伊马替尼的研发，作为晚期疾病的靶向治疗药物。然而，手术仍然是可切除原发性GIST的唯一治愈性治疗方法。这篇综述文章旨在回顾原发性GIST的治疗，研究复发情况，探讨手术在转移性疾病中的作用，并研究GIST的手术与分子治疗联合应用。
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