Ito Tomoki, Nakaya Aya, Fujita Shinya, Satake Atsushi, Nakanishi Takahisa, Azuma Yoshiko, Tsubokura Yukie, Konishi Akiko, Hotta Masaaki, Yoshimura Hideaki, Ishii Kazuyoshi, Nomura Shosaku
First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, Osaka 573-1010, Japan.
Leuk Res Rep. 2018 Jul 7;10:4-6. doi: 10.1016/j.lrr.2018.06.005. eCollection 2018.
Pure red cell aplasia (PRCA) is a rare disorder characterized by marked erythroid hypoplasia with maturation arrest in the bone marrow. Secondary acquired PRCA may be associated with hematologic disorders. A few case reports have described PRCA associated with multiple myeloma (MM). However, the clinical course and mechanism of PRCA associated with MM remain unknown. We herein report two cases of PRCA associated with MM in patients undergoing treatment with lenalidomide.
纯红细胞再生障碍性贫血（PRCA）是一种罕见的疾病，其特征是骨髓中显著的红系造血细胞发育不全并伴有成熟停滞。继发性获得性PRCA可能与血液系统疾病有关。有几例病例报告描述了PRCA与多发性骨髓瘤（MM）相关。然而，与MM相关的PRCA的临床病程和机制仍不清楚。我们在此报告两例在接受来那度胺治疗的患者中发生的与MM相关的PRCA病例。
