通过脑室内注射γ-氨基丁酸（GABA）激动剂或拮抗剂诱发雄性大鼠的同种攻击或防御行为。

Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.

作者信息

Depaulis A, Vergnes M

出版信息

Physiol Behav. 1985 Sep;35(3):447-53. doi: 10.1016/0031-9384(85)90322-1.

Abstract

The involvement of central GABAergic mechanisms in the control over offensive and defensive behaviours in the rat was studied using intracerebroventricular injections (5 microliter) of a GABA agonist (THIP) or a GABA antagonist (bicuculline methiodide). Intracerebroventricular injections of THIP (1.25 and 2.5 micrograms) induced attacks and offensive sideways towards an untreated partner, in animals placed in a neutral area where no aggressive reactions occur in controls. Social approach behaviours (partner investigation, allogrooming) were also increased in both attacking and non-attacking animals, whereas individual behaviours (cage exploration, autogrooming, immobile posture) were decreased. Inversely, intracerebroventricular injections of bicuculline methiodide (62.5 and 125 ng) suppressed offensive items (attacks, offensive sideways, upright postures) in resident animals confronted with untreated intruders and increased occurrence of defensive sideways. This treatment also decreased reactions oriented towards the partner (investigation, allogrooming and crawl under/over), while increasing individual behaviours (cage exploration, immobile posture). These data demonstrate that activation of central GABA receptors elicits intraspecific offensive behaviours in the rat. On the contrary, blockage of these receptors induces defensive reactions and suppresses offensive behaviours. The involvement of these receptors in the neural control over aggressive behaviour in the rat is discussed.

摘要

利用脑室内注射（5微升）γ-氨基丁酸（GABA）激动剂（4,5,6,7-四氢异噁唑[5,4-c]吡啶-3-醇，THIP）或GABA拮抗剂（碘化甲基荷包牡丹碱），研究了中枢GABA能机制在控制大鼠攻击和防御行为中的作用。向处于中性区域（在该区域对照组动物不会出现攻击反应）的动物脑室内注射THIP（1.25微克和2.5微克），可诱导其对未处理的同伴发起攻击和进行攻击性侧向移动。在攻击和未攻击的动物中，社交接近行为（对同伴的探究、相互梳理毛发）均增加，而个体行为（探索笼子、自我梳理毛发、静止姿势）则减少。相反，向与未处理入侵者对峙的常驻动物脑室内注射碘化甲基荷包牡丹碱（62.5纳克和125纳克），可抑制其攻击性行为（攻击、攻击性侧向移动、直立姿势），并增加防御性侧向移动的发生率。这种处理还减少了针对同伴的反应（探究、相互梳理毛发和从其下方/上方爬过），同时增加了个体行为（探索笼子、静止姿势）。这些数据表明，中枢GABA受体的激活会引发大鼠的种内攻击行为。相反，阻断这些受体则会诱导防御反应并抑制攻击行为。本文还讨论了这些受体在大鼠攻击行为神经控制中的作用。