Clark J T, Smith E R, Davidson J M
Physiol Behav. 1985 Oct;35(4):517-21. doi: 10.1016/0031-9384(85)90133-7.
Yohimbine HCL (2 mg/kg, 20 min prior to testing) administration was followed by significant decreases in the latencies to initial mount, intromission and ejaculation in castrated male rats bearing 2 mm testosterone-containing Silastic capsules 51 days after castration. Further, yohimbine stimulated copulatory activity in castrated, nonhormone-treated male rats up to 91 days after castration. Finally, yohimbine induced mounting in intact, nonreceptive female rats. These observations indicate that testosterone is not required for the enhancement of sexual motivation by yohimbine and support the suggestion that alpha 2-adrenoceptors are involved in the modulation of sexual arousal.
在去势 51 天后，给植入含 2 毫克睾酮的硅橡胶胶囊的去势雄性大鼠注射盐酸育亨宾（2 毫克/千克，测试前 20 分钟），随后其首次爬跨、插入和射精的潜伏期显著缩短。此外，育亨宾可刺激去势且未接受激素治疗的雄性大鼠的交配活动，这种刺激作用可持续至去势后 91 天。最后，育亨宾可诱导正常但未处于发情期的雌性大鼠出现爬跨行为。这些观察结果表明，育亨宾增强性动机并不需要睾酮，支持了α2 - 肾上腺素能受体参与性唤起调节的观点。
