组织病理学在高危骨髓增生异常综合征诊断中的应用
Histopathology in the diagnosis of high-risk myelodysplastic syndromes.
作者信息
Kayano Hidekazu
出版信息
J Clin Exp Hematop. 2018;58(2):51-60. doi: 10.3960/jslrt.18009.
Abstract
Myelodysplastic syndromes (MDS) are clonal diseases characterized by cytopenia and dysplasia in the peripheral blood, and risk of transition to acute myeloid leukemia (AML) in the bone marrow. In the current revision of the World Health Organization (WHO) classification for hematopoietic tissues, MDS are divided into low-, intermediate-, and high- risk groups according to their frequency of leukemic transformation and other biological indicators. Accuracy in histological evaluation plus blast counting on bone marrow biopsy is essential for the differentiation of high-risk MDS from AML. In this review, the value of histopathology in the diagnosis of high-risk MDS is discussed.
摘要
骨髓增生异常综合征（MDS）是一类克隆性疾病，其特征为外周血细胞减少和发育异常，以及骨髓有转化为急性髓系白血病（AML）的风险。在世界卫生组织（WHO）当前修订的造血组织分类中，MDS根据其白血病转化频率和其他生物学指标分为低危、中危和高危组。骨髓活检的组织学评估准确性加上原始细胞计数对于高危MDS与AML的鉴别至关重要。在本综述中，将讨论组织病理学在高危MDS诊断中的价值。
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