No information is available on the clinical use of abciximab during breastfeeding. Because abciximab is a large protein molecule with a molecular weight of 47,615 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] Until more data become available, abciximab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[3] If it is used by a nursing mother, monitor the infant for bruising and bleeding.
关于阿昔单抗在母乳喂养期间的临床应用尚无可用信息。由于阿昔单抗是一种分子量为47,615道尔顿的大分子蛋白质,乳汁中的含量可能非常低。[1]它也可能在婴儿胃肠道中被部分破坏,婴儿的吸收可能微乎其微。[2]在有更多数据可用之前,母乳喂养期间应谨慎使用阿昔单抗,尤其是在哺育新生儿或早产儿期间。产后至少等待2周再恢复治疗可能会减少对婴儿的药物传递。[3]如果哺乳期母亲使用了阿昔单抗,应监测婴儿是否有瘀伤和出血情况。