No information is available on the clinical use of guselkumab during breastfeeding. Because guselkumab is a large protein molecule with a molecular weight of about 144,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] Some expert guidelines consider guselkumab to be acceptable during breastfeeding.[3] Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[4]
关于哺乳期使用古塞库单抗的临床信息尚无可用资料。由于古塞库单抗是一种分子量约为144,000道尔顿的大蛋白质分子，乳汁中的含量可能非常低。[1]它也可能在婴儿胃肠道中被部分破坏，婴儿的吸收可能微乎其微。[2]一些专家指南认为哺乳期使用古塞库单抗是可以接受的。[3]产后至少等待2周再恢复治疗可能会将药物转移至婴儿的情况降至最低。[4]
