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去甲替林

Nortriptyline

Abstract

Because of the low levels of nortriptyline in breastmilk, amounts ingested by the infant are small and usually not been detected in the serum of the infant, although the less active metabolites are often detectable in low levels in infant serum. Immediate side effects have not been reported and a limited amount of follow-up has found no adverse effects on infant growth and development. A safety scoring system finds nortriptyline use to be possible with caution during breastfeeding.[1] Most authoritative reviewers consider nortriptyline one of the preferred antidepressants during breastfeeding.[2-4]

摘要

由于母乳中去甲替林水平较低,婴儿摄入的量很少,通常在婴儿血清中检测不到,不过活性较低的代谢产物在婴儿血清中常可检测到低水平。尚未报告有即刻副作用,且有限的随访发现对婴儿生长发育无不良影响。一种安全评分系统认为,母乳喂养期间可谨慎使用去甲替林。[1]大多数权威评审人员认为去甲替林是母乳喂养期间首选的抗抑郁药之一。[2-4]

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