Because of the low levels of sertraline in breastmilk, amounts ingested by the infant are small and is usually not detected in the serum of the infant, although the weakly active metabolite norsertraline (desmethylsertraline) is often detectable in low levels in infant serum. Rarely, preterm infants with impaired metabolic activity might accumulate the drug and demonstrate symptoms similar to neonatal abstinence. Most authoritative reviewers consider sertraline a preferred antidepressants during breastfeeding.[1-9]
由于母乳中舍曲林水平较低,婴儿摄入的量很少,通常在婴儿血清中检测不到,不过活性较弱的代谢产物去甲舍曲林(去甲基舍曲林)在婴儿血清中往往能检测到低水平。极少情况下,代谢活性受损的早产儿可能会蓄积该药物,并表现出类似于新生儿戒断的症状。大多数权威评论者认为舍曲林是母乳喂养期间首选的抗抑郁药。[1-9]