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咪康唑

Miconazole

Abstract

Because miconazole has poor absorption from the skin and vagina and has poor oral bioavailability, it is unlikely to adversely affect the breastfed infant, including after topical application to the nipples. However, miconazole ointment appears to have no advantage over lanolin for treating sore nipples during breastfeeding and a survey of members of the Academy of Breastfeeding Medicine found topical miconazole is rarely prescribed to nursing mothers to treat thrush.[1,2] Any excess cream or ointment should be removed from the nipples before nursing. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

摘要

由于咪康唑从皮肤和阴道的吸收较差,口服生物利用度也低,因此不太可能对母乳喂养的婴儿产生不利影响,包括在乳头局部应用后。然而,咪康唑软膏在治疗母乳喂养期间的乳头疼痛方面似乎并不比羊毛脂更具优势,并且一项针对母乳喂养医学学会成员的调查发现,局部应用咪康唑很少被开给哺乳期母亲用于治疗鹅口疮。[1,2] 喂奶前应将乳头处多余的乳膏或软膏清除。仅应将水溶性乳膏或凝胶产品涂抹于乳房,因为软膏可能会使婴儿通过舔舐接触到高剂量的矿物石蜡。[3]

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