The small amounts of midazolam excreted into breastmilk would not be expected to cause adverse effects in most breastfed infants. A safety scoring system finds midazolam acceptable to use during breastfeeding.[1] Two expert panels advocates waiting for at least 4 hours after a single intravenous dose of midazolam (e.g., for endoscopy) before resuming nursing.[2,3] With a newborn or preterm infant a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. After general anesthesia, breastfeeding can resume as soon as the mother has recovered sufficiently from general anesthesia to nurse.[4-6] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. With prolonged use (days) of intravenous therapy, an active metabolite can accumulate in the mother and might affect the infant, but data in breastfeeding are lacking. Monitor the infant for sedation, poor feeding and poor weight gain.
少量排泄到母乳中的咪达唑仑预计不会对大多数母乳喂养的婴儿造成不良影响。一种安全评分系统认为母乳喂养期间使用咪达唑仑是可以接受的。[1] 两个专家小组主张在单次静脉注射咪达唑仑(例如用于内窥镜检查)后至少等待4小时再恢复哺乳。[2,3] 对于新生儿或早产儿,谨慎的做法是在恢复哺乳前等待6至8小时。全身麻醉后,一旦母亲从全身麻醉中充分恢复到可以哺乳,就可以恢复母乳喂养。[4-6] 当在手术中使用多种麻醉剂组合时,遵循手术期间使用的最具问题药物的建议。对于长时间(数天)的静脉治疗,活性代谢物可能会在母亲体内蓄积并可能影响婴儿,但缺乏母乳喂养方面的数据。监测婴儿是否有镇静、喂养不良和体重增加不佳的情况。