Moser V C, MacPhail R C
Toxicol Lett. 1985 Nov;28(2-3):99-104. doi: 10.1016/0378-4274(85)90016-5.
We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2-5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for 8 days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an alpha 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz.
我们发现，单剂量的双甲脒（一种甲脒类杀虫剂）在给药后2至5天会导致小鼠死亡。为了进一步研究这一现象，在注射双甲脒（600毫克/千克，腹腔注射）前，对成年雌雄白化小鼠分别用育亨宾（10毫克/千克，腹腔注射）或去离子水（6毫升/千克，腹腔注射）进行处理，此后每天两次，持续8天。接受水治疗的雄性小鼠比接受水治疗的雌性小鼠对双甲脒的致死作用更敏感。此外，育亨宾处理显著降低了两性的死亡数量。这些数据表明，α2-肾上腺素能机制参与了双甲脒产生的延迟致死作用。
