Konobasova N V, Sal'nikov K V
Tsitologiia. 1985 Oct;27(10):1192-7.
A study was made of the dependence of ATP hydrolysis intensity upon different ratios of sodium and potassium ions in plasma membrane of L cells and of cells of clone Lebr 625, sensitive and resistant to ethidium bromide, and of the distribution of cells according to cell cycle phases in dense and sparse cultures. In dense cultures, the cell growth is arrested on G1 phase, the hydrolytic activity of (Na+ + K+)-ATPase decreases, and the Na+, K+ ratio for maximum activity of (Na+ + K+)-ATPase changes. The higher proliferative activity of Lebr 625 cells in dense culture corresponds to the higher hydrolytic activity of (Na+ + K+)-ATPase.
对L细胞、对溴化乙锭敏感和耐药的Lebr 625克隆细胞的质膜中ATP水解强度对钠钾离子不同比例的依赖性，以及致密培养和稀疏培养中细胞根据细胞周期阶段的分布进行了研究。在致密培养中，细胞生长停滞在G1期，（Na+ + K+）-ATP酶的水解活性降低，（Na+ + K+）-ATP酶最大活性时的Na+、K+比例发生变化。Lebr 625细胞在致密培养中的较高增殖活性对应于（Na+ + K+）-ATP酶的较高水解活性。
