Kiyokawa T, Kawaguchi T, Seiki M, Yoshida M
Virology. 1985 Dec;147(2):462-5. doi: 10.1016/0042-6822(85)90149-7.
Human T-cell leukemia virus type I (HTLV-I) contains a unique gene pX coding for p40 chi, and this protein was suggested to activate the transcription from the LTR of HTLV. By a similar mechanism, this viral function might be involved in immortalization of T-cells and leukemogenesis in adult T-cell leukemia induced by HTLV-I. In this communication, a part of the p40 chi was found to be tightly associated with nuclei in infected cell lines by subcellular fractionation and immunofluorescence staining.
人类嗜T淋巴细胞病毒I型（HTLV-I）含有一个编码p40 chi的独特基因pX，有人认为该蛋白可激活HTLV长末端重复序列（LTR）的转录。通过类似机制，这种病毒功能可能参与了HTLV-I诱导的T细胞永生化及成人T细胞白血病的白血病发生过程。在本交流中，通过亚细胞分级分离和免疫荧光染色发现，p40 chi的一部分在感染的细胞系中与细胞核紧密相关。
