Bruno Valentina, Martelli Federica, Capogna Maria Vittoria, Youssef Aly, Bruno Antonella, Ticconi Carlo, Piccione Emilio, Pietropolli Adalgisa
Academic Department of Biomedicine and Prevention, and Clinical Department of Surgery, University of Rome "Tor Vergata", Section of Gynecology and Obstetrics, Tor Vergata University Hospital, Rome, Italy.
Department of Obstetrics and Gynecology, Sant'Orsola - Malpighi Hospital, University of Bologna, Bologna, Italy.
J Matern Fetal Neonatal Med. 2020 Mar;33(5):726-730. doi: 10.1080/14767058.2018.1500541. Epub 2018 Sep 6.
To evaluate the effects of chorionic villus sampling (CVS) on placental volume (PV), perfusion, and vasculature in the first trimester of pregnancy. Uterine artery pulsatility index (PI), PV, vascularization index (VI), flow index (FI), and Vascularization Flow Index (VFI) were serially measured in 38 pregnant women who underwent CVS. Thirty-eight women who did not undergo invasive prenatal diagnosis were recruited as controls. CVS was associated with a mild reduction of PI, a reduction of placental VI, FI, and VFI and with an increase in PV detected one week after the procedure. The outcome of pregnancy was similar between women of the two groups. Our findings showed that CVS is associated with mild placental vascular and morphological changes. However, these changes do not seem to be associated with adverse outcome.
评估绒毛取样（CVS）对妊娠早期胎盘体积（PV）、灌注及血管系统的影响。对38例行CVS的孕妇连续测量子宫动脉搏动指数（PI）、PV、血管化指数（VI）、血流指数（FI）及血管化血流指数（VFI）。招募38例未行侵入性产前诊断的孕妇作为对照。CVS与PI轻度降低、胎盘VI、FI及VFI降低相关，且与术后1周检测到的PV增加相关。两组孕妇的妊娠结局相似。我们的研究结果表明，CVS与胎盘血管及形态的轻度改变有关。然而，这些改变似乎与不良结局无关。
