Joyner R W, Overholt E D
Am J Physiol. 1985 Dec;249(6 Pt 2):H1228-31. doi: 10.1152/ajpheart.1985.249.6.H1228.
The effects of 0.2 mM octanol on action potential propagation were investigated using in vitro preparations of canine papillary muscles. In these preparations an action potential initiated in the superficial Purkinje (P) layer propagates across specific Purkinje-ventricular junction (PVJ) sites into the underlying ventricular (V) layer. The conduction delay at PVJ sites increased from 4.85 +/- 1.55 to 8.85 +/- 3.34 (mean +/- SD) ms (n = 10, P less than 0.005), an 82% increase. However, propagation within the V syncytium was much less affected, with a decrease of conduction velocity by only 10% and a decrease in the maximal rate of rise of the action potential of 23%. The results indicate that octanol, which has previously been shown to increase gap junctional resistance, has a preferential effect on PVJ sites, as predicted by the hypothesis that there is a restricted pathway for intracellular current flow from P cells to V cells at these sites.
使用犬乳头肌的体外制备物研究了0.2 mM辛醇对动作电位传播的影响。在这些制备物中，起源于表层浦肯野（P）层的动作电位通过特定的浦肯野 - 心室连接（PVJ）部位传播到下方的心室（V）层。PVJ部位的传导延迟从4.85±1.55增加到8.85±3.34（平均值±标准差）毫秒（n = 10，P < 0.005），增加了82%。然而，V细胞融合体内的传播受影响较小，传导速度仅降低10%，动作电位的最大上升速率降低23%。结果表明，先前已证明能增加缝隙连接电阻的辛醇对PVJ部位有优先作用，正如以下假设所预测的，即在这些部位存在从P细胞到V细胞的细胞内电流流动的受限途径。
