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纳米片在前沿细胞研究中的应用。

Applications of Nanosheets in Frontier Cellular Research.

作者信息

Huang Wenjing, Sunami Yuta, Kimura Hiroshi, Zhang Sheng

机构信息

Micro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan.

Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

出版信息

Nanomaterials (Basel). 2018 Jul 12;8(7):519. doi: 10.3390/nano8070519.

Abstract

Several types of nanosheets, such as graphene oxide (GO) nanosheet, molybdenum disulfide (MoS₂) and poly(l-lactic acid) (PLLA) nanosheets, have been developed and applied in vitro in cellular research over the past decade. Scientists have used nanosheet properties, such as ease of modification and flexibility, to develop new cell/protein sensing/imaging techniques and achieve regulation of specific cell functions. This review is divided into three main parts based on the application being examined: nanosheets as a substrate, nanosheets as a sensitive surface, and nanosheets in regenerative medicine. Furthermore, the applications of nanosheets are discussed, with two subsections in each section, based on their effects on cells and molecules. Finally, the application prospects of nanosheets in cellular research are summarized.

摘要

在过去十年中,已经开发了几种类型的纳米片,例如氧化石墨烯(GO)纳米片、二硫化钼(MoS₂)和聚(L-乳酸)(PLLA)纳米片,并将其应用于细胞研究的体外实验。科学家们利用纳米片易于修饰和柔韧性等特性,开发了新的细胞/蛋白质传感/成像技术,并实现了对特定细胞功能的调控。根据所研究的应用,本综述分为三个主要部分:纳米片作为基质、纳米片作为敏感表面以及纳米片在再生医学中的应用。此外,基于纳米片对细胞和分子的影响,在每个部分中又分为两个子部分来讨论纳米片的应用。最后,总结了纳米片在细胞研究中的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ef1/6070807/51adfc4c4640/nanomaterials-08-00519-g001.jpg

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