Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany.
Sci Rep. 2018 Jul 12;8(1):10549. doi: 10.1038/s41598-018-28910-z.
Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors. Hypothermia reduced the long term effect of shock wave exposure. Thus, we present an effective C. elegans model of long term effects of blast-related mild traumatic brain injury, as well as evidence of the merit of therapeutic hypothermia as a therapy option following blast exposure.
爆炸相关的轻度创伤性脑损伤会导致严重的长期健康问题，但治疗方法仍不够完善。治疗性低温已被认为是一种潜在有效的治疗方法。在秀丽隐杆线虫模型中，我们证明了暴露于类似爆炸的冲击波后，寿命呈剂量依赖性降低。使用聚乙烯醇，我们表明空化是破坏冲击波成分的关键损伤因素。短寿命和长寿命秀丽隐杆线虫突变体表现出遗传和环境长寿决定因素的相互作用。低温降低了冲击波暴露的长期影响。因此，我们提出了一种有效的秀丽隐杆线虫模型，用于研究爆炸相关的轻度创伤性脑损伤的长期影响，并证明了治疗性低温作为爆炸暴露后的治疗选择的优点。
