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不全骨折:类风湿关节炎3例患者足踝疼痛的罕见病因。

Insufficiency fractures: A rare cause of foot and ankle pain in three patients with rheumatoid arthritis.

作者信息

Hillyard Katherine C L, Shabbir Shabnam, Sirisena Udawattage Nadeeka, Hogarth Maxine, Sahu Ajay

机构信息

Radiology Department, Ealing Hospital, Uxbridge Rd, Southall, London UB1 3HW, UK.

出版信息

Radiol Case Rep. 2018 Jun 29;13(4):855-861. doi: 10.1016/j.radcr.2018.05.016. eCollection 2018 Aug.

DOI:10.1016/j.radcr.2018.05.016
PMID:30002787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6039983/
Abstract

Insufficiency fractures are recognized but rare complications in patients with longstanding rheumatoid arthritis. Such fractures are typically solitary and are rarely seen to affect the foot and ankle. We describe 3 women with longstanding rheumatoid arthritis, treated with one, or a combination of, corticosteroids, DMARDs and anti-TNF, presenting with foot and ankle pain with no prior history of trauma. MRIs showed rare multiple florid insufficiency fractures of the foot and ankle, in 2 cases bilaterally, which were managed conservatively. These cases highlight the importance of considering insufficiency fractures in similar patients presenting with foot and ankle pain. Radiographs may fail to demonstrate these lesions, delaying diagnosis, and worsening patient outcome, therefore in such cases MRI is a valuable modality.

摘要

应力性骨折在长期类风湿性关节炎患者中虽已被认识到,但却是罕见的并发症。此类骨折通常为单发,很少累及足踝部。我们描述了3例长期类风湿性关节炎女性患者,她们接受了皮质类固醇、改善病情抗风湿药(DMARDs)和抗肿瘤坏死因子(anti-TNF)单一或联合治疗,出现足踝部疼痛且无既往创伤史。磁共振成像(MRI)显示足部和踝部罕见的多发活动性应力性骨折,2例为双侧受累,均采用保守治疗。这些病例强调了在出现足踝部疼痛的类似患者中考虑应力性骨折的重要性。X线片可能无法显示这些病变,从而延误诊断并使患者预后恶化,因此在这种情况下,MRI是一种有价值的检查方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/5285b31ce416/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/5285b31ce416/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/d402e90f8c3b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/b848b19ff84b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/0f66742364f0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/426764ba9103/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/7614f3168b8f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/a2065b63a98c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/b5ebf7b29d8d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/5c7c9f5ec035/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bcb/6039983/5285b31ce416/gr9.jpg

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本文引用的文献

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Acute and Stress-related Injuries of Bone and Cartilage: Pertinent Anatomy, Basic Biomechanics, and Imaging Perspective.骨与软骨的急性及应激相关损伤:相关解剖学、基础生物力学及影像学视角
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Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis.类风湿关节炎的流行病学、病理生理学和诊断概述。
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Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk.糖皮质激素治疗的类风湿性关节炎小鼠模型中骨脆性的机制:对骨质疏松性骨折风险的影响
Arthritis Rheum. 2012 Nov;64(11):3649-59. doi: 10.1002/art.34639.
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Spontaneous talar and calcaneal fracture in rheumatoid arthritis: a case report.类风湿关节炎伴距骨和跟骨自发性骨折:一例报告
J Radiol Case Rep. 2011;5(7):15-23. doi: 10.3941/jrcr.v5i7.735. Epub 2011 Jul 1.
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Multiple pelvic insufficiency fractures in rheumatoid patients with mutilating changes.患有毁形性改变的类风湿患者出现多发性骨盆不全骨折。
Orthop Rev (Pavia). 2009 Oct 10;1(2):e23. doi: 10.4081/or.2009.e23.
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Imaging of insufficiency fractures.应力性骨折的影像学检查
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Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis.类风湿关节炎患者大型基于人群队列中的骨质疏松性骨折风险。
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Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis.在炎症性关节炎中,成骨细胞功能在局灶性骨侵蚀部位受损。
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