Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical College, Zunyi, Guizhou 563003, China.
Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical College, Zunyi, Guizhou 563003, China.
Biomed Res Int. 2018 May 29;2018:9623412. doi: 10.1155/2018/9623412. eCollection 2018.
MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate posttranscriptional expression of target genes. Accumulating evidences have demonstrated that the miR-30 family, as a member of microRNAs, played a crucial regulating role in the development of tissues and organs and the pathogenesis of clinical diseases, which indicated that it may be a promising regulator in development and disease. This review aims to clarify the current progress on the regulating role of miR-30 family in tissues and organs development and related disease and highlight their research prospective in the future.
MicroRNAs (miRNAs) 是一类小型的非编码 RNA，可以负向调控靶基因的转录后表达。越来越多的证据表明，miR-30 家族作为 microRNAs 的一员，在组织和器官的发育以及临床疾病的发病机制中发挥着关键的调节作用，这表明它可能是一种有前途的发育和疾病调节剂。本综述旨在阐明 miR-30 家族在组织和器官发育及相关疾病中的调节作用的最新进展，并强调其未来的研究前景。
