Chiba Y, Miura J, Nakao T, Wakisaka A, Kunikane K
Biken J. 1985 Jun;28(1-2):1-7.
The effect of HLA on varicella-zoster virus (VZV)-specific lymphocyte transformation (LTF) was studied in 100 normal immune adults and 64 children who were immunized with live attenuated varicella vaccine. In the normal adults, a statistically significant association was observed between low responsiveness and the presence of A2 (p less than 0.025), and also between high responsiveness and the presence of Aw24 (p less than 0.05). A similar but clearer association, i.e. low responsiveness with A2 (p less than 0.005) and high responsiveness with Aw24 (p less than 0.025), was observed in the vaccinated children. In these children, Aw31 was also found to be related to low responsiveness (p less than 0.05). These results suggest that the VZV-specific cellular immune response is in some way influenced by HLA.
在100名正常免疫的成年人以及64名接种了减毒活水痘疫苗的儿童中，研究了人类白细胞抗原（HLA）对水痘-带状疱疹病毒（VZV）特异性淋巴细胞转化（LTF）的影响。在正常成年人中，观察到低反应性与A2的存在之间存在统计学显著关联（p<0.025），高反应性与Aw24的存在之间也存在统计学显著关联（p<0.05）。在接种疫苗的儿童中观察到了类似但更明显的关联，即低反应性与A2相关（p<0.005），高反应性与Aw24相关（p<0.025）。在这些儿童中，还发现Aw31与低反应性有关（p<0.05）。这些结果表明，VZV特异性细胞免疫反应在某种程度上受HLA影响。
