白三烯A4在人多形核白细胞中的生物活性研究。
Investigations of the biological activity of leukotriene A4 in human polymorphonuclear leukocytes.
作者信息
Beckman J K, Gay J C, Brash A R, Lukens J N, Oates J A
出版信息
Biochem Biophys Res Commun. 1985 Nov 27;133(1):23-9. doi: 10.1016/0006-291x(85)91836-4.
PMID:3000375
Abstract
An investigation was undertaken to compare the responses of human neutrophils to the epoxide leukotriene A4 with those elicited by its stable product leukotriene B4 under identical IN VITRO conditions. LTA4 evokes neutrophil responses similar in nature to those induced by LTB4 but at much higher concentrations. Evidence suggests that LTA4 is important primarily for its role as an intermediate rather than for inherent activity.
摘要
开展了一项研究，以比较在相同体外条件下人类中性粒细胞对环氧白三烯A4（LTA4）和其稳定产物白三烯B4（LTB4）的反应。LTA4引发的中性粒细胞反应在性质上与LTB4诱导的反应相似，但浓度要高得多。有证据表明，LTA4主要因其作为中间体的作用而非固有活性而重要。
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