61-91β-促脂解素对大鼠的僵住效应
Cataleptic effect of 61-91 beta-lipotropic hormone in rat.
作者信息
Motomatsu T, Seidah N, Chrétien M
出版信息
Can J Neurol Sci. 1977 Feb;4(1):49-52.
PMID:300038
Abstract
Intraventricular administration of a peptide from ovine pituitaries whose structure is identical to the 61-91 C-terminal portion of beta-lipotropic hormone (61-91 beta-LPH) induced catalepsy, muscular hypertonus and analgesia in rats. Naloxone inhibited both the analgesic and cataleptic effects. 1-dihydroxyphenylalanine (1-DOPA) completely prevented the cataleptic effect. The cataleptic effect of 61-91 beta-LPH was potentiated by 1-5-hydroxytryptophan (5-HTP).
摘要
向大鼠脑室内注射一种来自绵羊垂体的肽，其结构与β-促脂素（61-91β-LPH）的61-91 C末端部分相同，可诱导大鼠出现僵住症、肌肉张力亢进和镇痛作用。纳洛酮可抑制镇痛和僵住症效应。左旋多巴（1-DOPA）可完全预防僵住症效应。5-羟色氨酸（5-HTP）可增强61-91β-LPH的僵住症效应。
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