Molecolar Biology and Viral Oncology Unit, Istituto Nazionale Tumori "Fondazione G. Pascale"- IRCCS, Naples, Italy.
Mini Rev Med Chem. 2018;18(18):1567-1571. doi: 10.2174/1389557518666180713112119.
The epithelium of the gastrointestinal tract is densely populated by complex microbial communities which exert both local and distant effects in the human body with relevant consequences on the metabolic status, immune system and overall health. A dynamic equilibrium between the many bacterial species and the host intestinal epithelium is maintained through the release of a large number of small molecules and peptides. The quorum sensing peptides are mainly secreted by Gram-positive bacteria and are able to "communicate" with human cells. Some sensing peptides have shown to promote angiogenesis, tumor cell invasion and metastasis of colon cancer as well as of breast cancer cells. On the other hand, quorum sensing cyclodipeptides produced by bacteria and fungi have shown significant antitumor activities. In this review, we summarize the available data on the pro-tumor activities of quorum sensing peptides and the anti-cancer functions of cyclodipeptides in the human malignancies.
胃肠道的上皮细胞密集分布着复杂的微生物群落，这些微生物群落对人体产生局部和远处的影响，对代谢状态、免疫系统和整体健康产生相关影响。通过释放大量的小分子和肽，许多细菌物种与宿主肠道上皮之间保持着动态平衡。群体感应肽主要由革兰氏阳性菌分泌，能够与人类细胞“交流”。一些感应肽已被证明可促进结肠癌和乳腺癌细胞的血管生成、肿瘤细胞侵袭和转移。另一方面，细菌和真菌产生的群体感应环二肽表现出显著的抗肿瘤活性。在这篇综述中，我们总结了关于群体感应肽的促肿瘤活性以及环二肽在人类恶性肿瘤中的抗癌功能的现有数据。
