Liao Guangjie, Zhang Xinke, Li Zhongjian, Lan Su, Huang Miaoli, Huang Weijian
Department of Pathology, Red Cross Hospital of Yulin, Yulin, China.
Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Indian J Pathol Microbiol. 2018 Jul-Sep;61(3):431-433. doi: 10.4103/IJPM.IJPM_396_17.
We analyzed the clinicopathological features of renal-type clear cell carcinoma (RTCCC) in the prostate and its diagnosis according to the example in our hospital and review of the literature. Clinicopathological features of RTCCC in the prostate were observed in a patient from our hospital combining with a review of the literature. Microscopically, the tumor was composed of cells with abundant and translucent cytoplasm, arranged in the form of the vesicular nest or glandular structure. Therefore, it was necessary to distinguish between metastatic clear cell renal cell carcinoma and primary RTCCC in the prostate. Immunohistochemistry (IHC) of this case showed tumor cells were positive expression for cytokeratin (CKpan), low-molecular weight cytokeratin, epithelial membrane antigen, and prostate-specific antigen (PSA), P504S, prostate-specific membrane antigen and partial positive expression for vimentin and CD10. The tumor cells displayed negative expression of high molecular weight cytokeratin, cytokeratin 7 (CK7), CK34, PAX8, and renal cell carcinoma. The morphological and immunohistochemical features of this tumor were in correspondence with RTCCC of the prostate. This tumor is a rare variant of the prostate carcinomas. To the best of our knowledge, this type of extrarenal tumor has only been reported in six previous studies. Combination of histology, IHC, imaging, and serum PSA is needed to perform a suitable diagnosis.
我们结合我院病例并复习文献，分析了前列腺肾型透明细胞癌（RTCCC）的临床病理特征及其诊断方法。通过我院1例患者的观察并复习文献，总结了前列腺RTCCC的临床病理特征。显微镜下，肿瘤由胞质丰富且透明的细胞组成，呈囊状巢或腺管结构排列。因此，有必要鉴别前列腺转移性透明细胞肾细胞癌和原发性RTCCC。该病例的免疫组化（IHC）显示肿瘤细胞对角蛋白（CKpan）、低分子量角蛋白、上皮膜抗原、前列腺特异性抗原（PSA）、P504S、前列腺特异性膜抗原呈阳性表达，波形蛋白和CD10呈部分阳性表达。肿瘤细胞高分子量角蛋白、细胞角蛋白7（CK7）、CK34、PAX8和肾细胞癌呈阴性表达。该肿瘤的形态学和免疫组化特征符合前列腺RTCCC。此肿瘤是前列腺癌的一种罕见变异型。据我们所知，这种肾外肿瘤此前仅有6项研究报道过。需要结合组织学、IHC、影像学及血清PSA进行恰当诊断。
